Wednesday, June 27, 2012

Efforts to develop new drugs that hopefully will never be used

Efforts to develop new drugs that hopefully will never be used [ Back to EurekAlert! ] Public release date: 27-Jun-2012
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Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Concerns about terrorist attacks, the prospect of a rogue nation using nuclear weapons and the Fukushima power plant accident in Japan are fostering efforts to develop a new family of drugs that everyone hopes will never be used, according to an article in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.

Ann M. Thayer, C&EN senior correspondent, explains that the federal government has launched programs to develop medical countermeasures against nuclear threats. Radiation releases can happen under various circumstances, including failure of safety systems at commercial nuclear power plants and terrorist attacks. The article describes programs run by the U.S. Food & Drug Administration (FDA), the U.S. Department of Health and Human Services and the National Institutes of Health that support several small companies as they try to develop drugs to treat acute radiation syndrome (ARS).

The article discusses the companies' approaches. Some seek to adapt existing drugs, including treatments for the side effects of radiation therapy for cancer. Thayer notes that because these drugs are already approved by the FDA, stockpiling them would be easier. Others are looking for new compounds that can treat the symptoms of ARS or remove radioactive particles from the body.

###

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.


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Efforts to develop new drugs that hopefully will never be used [ Back to EurekAlert! ] Public release date: 27-Jun-2012
[ | E-mail | Share Share ]

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Concerns about terrorist attacks, the prospect of a rogue nation using nuclear weapons and the Fukushima power plant accident in Japan are fostering efforts to develop a new family of drugs that everyone hopes will never be used, according to an article in the current edition of Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, the world's largest scientific society.

Ann M. Thayer, C&EN senior correspondent, explains that the federal government has launched programs to develop medical countermeasures against nuclear threats. Radiation releases can happen under various circumstances, including failure of safety systems at commercial nuclear power plants and terrorist attacks. The article describes programs run by the U.S. Food & Drug Administration (FDA), the U.S. Department of Health and Human Services and the National Institutes of Health that support several small companies as they try to develop drugs to treat acute radiation syndrome (ARS).

The article discusses the companies' approaches. Some seek to adapt existing drugs, including treatments for the side effects of radiation therapy for cancer. Thayer notes that because these drugs are already approved by the FDA, stockpiling them would be easier. Others are looking for new compounds that can treat the symptoms of ARS or remove radioactive particles from the body.

###

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Tuesday, June 26, 2012

Pool Construction in Leshan | Indoor Swimming Pool Guide

The best quality materials will be wasted without proper installation. For your pool construction in Leshan, workmanship quality is key and if you can afford it, you should call pool construction experts. If you do not want to spend lots of money, you can supervise your pool construction carefully.

Indoor Swimming Pool Construction in Leshan

Be aware that if they are not experts with over 5 years experience in indoor swimming pool building, most construction workers in Leshan will not be familiar with the specialized materials and techniques required. Hence, before the construction begins, you have to make sure that each pool worker understands the importance of the materials and their proper installation.

 Indoor swimming pool construction in Leshan

Also, coordinate carefully different suppliers work and where they overlap. If you can, daily review construction and installation of materials to find problems before they become hidden from view.
These tips will ensure your swimming pool construction in Leshan at good quality standards for a reasonable price.

Selecting a Contractor for your Swimming Pool Construction in Leshan

In Leshan, any contracting job including swimming pool construction or repair that costs over $500 must be performed by a contractor who holds a current, valid contractors license usually in the classification for which they are contracting. Contractors who build or repair swimming pools must be licensed as swimming pool specialty contractors.

A general building contractor may also contract for swimming pool construction in Leshan provided the general building contractor holds the swimming pool specialty classification, or the general building contractor hires a licensed swimming pool specialty contractor to perform the work in Leshan.

Other contractors like plumbers, landscapers, solar workers, etc., should work within their specific areas of licensure in Leshan, and cannot be responsible for the overall project.

Homeowners who are considering swimming pool construction may work with a salesperson. The law does allow licensed contractors to employ registered home improvement salespersons (HIS) to solicit, negotiate, sell, or execute contracts, including swimming pool construction and repair.

Tips for Choosing your Pool Contractor in Leshan

- Get referrals: It is a good idea to ask friends or family for referrals before hiring a pool contractor or service company. You may also get referrals from trade associations, such as a local builders? exchange or a Leshan swimming pool and spa association.
- Get references: You should ask for references from the contractor, at least one current and one completed in Leshan. When you call to talk with the client about the job, be sure to ask how the project was handled and about their satisfaction with the contractor, sub-contractors and employees, as well as the end result for the completed job.
- Get bids: It is important to get at least three bids in Leshan so you can compare them.
- Verify the license or registration: Make sure to verify that the contractors license or registration is in the name that is presented to you and that it is current and active. Ask the contractor or salesperson to see their identification and check that the name of the Leshan swimming pool company with which you are doing business is listed.
- Have a contract: make sure everything is in writing. This includes materials, schedule and clean-up. Changes, details and payment scheduled should be written down in detail. Do not sign anything until you completely understand the terms. A plan and scale drawing of the shape, size, and dimensions must be included as part of your swimming pool contract in Leshan.

Related posts:

  1. Pool Heating Systems in Leshan
  2. Pool Covers in Leshan
  3. Pool Dehumidifiers in Leshan
  4. Indoor Swimming Pool in Leshan
  5. Indoor Pool Design and Architecture in Leshan

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HSBC in bid to evict Hong Kong Occupy protesters

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Factors To Check When Choosing Plumbing Services Tacoma ...

Plumbing is one of the most important house improvement tasks done in most homesteads. When in need of repairing an existing system, it is important that a quality job is done to avoid subsequent costs of repair. The best way to have a quality project done is making the right choice when choosing plumbing services Tacoma providers. The following are factors which you should consider when choosing these service providers.

Locating these professionals can be done through asking for referrals from friends and neighbors or searching online. If you decide to search online, consider reading reviews of specific firms before contacting them. This mechanism is best especially if you are a new resident in Tacoma.

The cost of is another important consideration. Plumbers charge rates that differ depending on how quality their projects are. However, established service providers are expected to inspect the scope of work before giving an estimate or quote. Remember that the cheapest services could also mean the lowest quality offered.

The costs of home improvement are sometimes very high and if anything goes wrong during the project you might be subjected to more spending. It is very beneficial to choose plumbers who offer insurance covered service. The insurance policy should include both worker compensation and general liability.

Experience and quality of projects handled in the past should also be subject to evaluation. Experience plumbers know how best to handle their projects to the satisfaction of their clients. You can thus check how many years the company has been in business and how qualified their technicians are.

When choosing Plumbing Services Tacoma, it is important that the right choice be made. Consider locating at least three service providers and interview them to find the most suitable one. Among the things that should be checked during this interview are experience levels and provision of an insurance covered project.

Click here for more information about Factors To Consider When Choosing Plumbing Services Tacoma .

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Ultra-Orthodox Jews protest Israel military draft

Abir Sultan / EPA

Thousands of ultra-Orthodox Jews participate in a prayer rally and protest against the Israeli government's intention to recruit Yeshiva students to the army and civil service, in the neighborhood of Mea Shearim in Jerusalem on June 25, 2012.

Thousands of Ultra-Orthodox Jews joined an early-morning prayer rally in Jerusalem on Monday to protest against government moves which could bring to an end the exemption of yeshiva students?from mandatory military service. ?

The Israeli newspaper Haaretz reports that?Pini Rosenberg, one of the speakers at the rally, said: "Instead of preparing the prisons for immigrants from Sudan, we suggest to those haters of religion to prepare 50 thousand places of detention for yeshiva students who will refuse to be drafted."

Menahem Kahana / AFP - Getty Images

Ultra-Orthodox Jews pray early on Monday morning in the Sabbath Square at the heart of the Jewish neighbourhood in Jerusalem during a protest against the replacement to the Tal Law, that exempts ultra-Orthodox Yeshiva students from mandatory military service.

Abir Sultan / EPA

An Ultra-Orthodox man wearing burlap as a sign of mourning takes part in a prayer rally in Mea Shearim.

Abir Sultan / EPA

Boys watch from the sidelines of the rally.

?

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Court ruling leaves Ariz. to rely on feds

Arizona Gov. Jan Brewer answers a question during a brief news conference as she reacts to the United States Supreme Court decision regarding Arizona's controversial immigration law, SB1070, coming down at the Arizona Capitol Monday, June 25, 2012, in Phoenix. The Supreme Court struck down key provisions of Arizona?s crackdown on immigrants Monday but said a much-debated portion on checking suspects? status could go forward Monday, June 25, 2012, in Phoenix.(AP Photo/Ross D. Franklin)

Arizona Gov. Jan Brewer answers a question during a brief news conference as she reacts to the United States Supreme Court decision regarding Arizona's controversial immigration law, SB1070, coming down at the Arizona Capitol Monday, June 25, 2012, in Phoenix. The Supreme Court struck down key provisions of Arizona?s crackdown on immigrants Monday but said a much-debated portion on checking suspects? status could go forward Monday, June 25, 2012, in Phoenix.(AP Photo/Ross D. Franklin)

Rosa Maria Soto, right, and Maria Durand, both from Arizona, cheer as they react to the United States Supreme Court decision regarding Arizona's controversial immigration law, SB1070, comes down at the Arizona Capitol Monday, June 25, 2012, in Phoenix. The Supreme Court struck down key provisions of Arizona?s crackdown on immigrants Monday but said a much-debated portion on checking suspects? status could go forward. (AP Photo/Ross D. Franklin)

Members of Promise Arizona, Leonila Martinez, left, Patricia Rosas, and Gustavo Cruz, right, react to the United States Supreme Court decision regarding Arizona's controversial immigration law, SB1070, as the ruling comes down at the Arizona Capitol Monday, June 25, 2012, in Phoenix. The Supreme Court struck down key provisions of Arizona?s crackdown on immigrants Monday but said a much-debated portion on checking suspects? status could go forward.Monday, June 25, 2012, in Phoenix.(AP Photo/Ross D. Franklin)

Arizona Gov. Jan Brewer speaks to the media after the U.S. Supreme Court's decision on Arizona's immigration law, SB 1070, on Monday, June 25, 2012 in Phoenix. The Supreme Court threw out key provisions of Arizona's crackdown on illegal immigrants Monday but said a much-debated portion, that police must check the status of people stopped for various reasons who might appear to be in the U.S. illegally could go forward. (AP Photo/The Arizona Republic, Nick Oza) MAGS OUT; NO SALES

Arizona Gov. Jan Brewer leaves a news conference responding to the United States Supreme Court decision regarding Arizona's controversial immigration law, SB1070, coming down at the Arizona Capitol Monday, June 25, 2012, in Phoenix. The Supreme Court struck down key provisions of Arizona?s crackdown on immigrants Monday but said a much-debated portion on checking suspects? status could go forward. (AP Photo/Ross D. Franklin)

(AP) ? For all the declarations of victory, the U.S. Supreme Court's decision to preserve the "show me your papers" provision in Arizona's immigration law means the state can enforce the statute only with the help of its chief critic: the federal government.

The court's decision Monday struck down parts of the law, but preserved one that requires local police to check the immigration status of people stopped for various reasons and whom officers believe are in the country illegally.

There was a catch, however. The court decided that officers cannot detain anyone on an immigration violation. That is, unless federal immigration officials say so.

Sheriff Joe Arpaio, the controversial lawman known for his anti-immigration raids, said he was concerned whether federal agents will decline to pick up some illegal immigrants who are stopped by his deputies.

"I have my suspicions," he said.

Hours after the ruling, the Department of Homeland Security canceled agreements with seven Arizona police departments that deputized officers to arrest people on immigration violations while on street patrol.

Federal immigration officers will help, but only if doing so conforms to the department's priorities, including catching repeat violators and identifying and removing those who threaten public safety and national security, the department said.

If federal agents decline to pick up immigrants, the state doesn't have any way to force federal authorities to pick them up and will likely have to let them go unless they're suspected of committing a crime that would require them to be brought to jail, said Peter Spiro, a Temple University law professor who specializes in immigration law.

In that sense, the law is symbolic, Spiro said. "(The questioning requirement) is useful to the extent that it allows states to give notice of hostilities to undocumented immigrants," Spiro said. "It allows for a formal expression of the state's hostilities toward undocumented immigrants."

Meanwhile, if local police get the chance to enforce the law and are not blocked by a federal injunction, they will be closely watched not just by immigrant rights advocates who are on the lookout for racial profiling.

They will also face scrutiny from residents who have been frustrated by and blamed the federal government for a porous border and can under the immigration law sue police departments that don't follow the "show me your papers" provision.

A federal hotline was set up for the public to report potential civil rights concerns.

Immigrant rights advocates plan to launch a public relations campaign in hopes of quelling fears about the law and hold public meetings across the state to explain the law. A hotline run by a civil rights group will take questions about the law and document reports of abuses by police.

About 50 immigrant rights supporters rallied peacefully outside an Immigration and Customs Enforcement office near downtown Phoenix.

Arizona Gov. Jan Brewer called the decision a victory for all Americans, but said she expected lawsuits to challenge the implementation of the law.

"It's certainly not the end of our journey," she said.

And responding to criticism that the law would lead to racial profiling, Brewer said that any officer who violates a person's civil rights will be held accountable. Even while upholding the provision, the justices said the status check could be challenged.

Homeland Security Secretary Janet Napolitano said in a written statement that the Supreme Court's ruling will make her agency's work more challenging, but she was pleased that the court ruled state laws can't dictate the federal government's immigration enforcement priorities.

Immigration rights groups said they were surprised and disappointed by the court's decision, and planned to ask the lower courts to block the law.

"The opinion invites the challenges that we are bringing. It's going to cause racial profiling. It will cause prolonged detentions," said Linton Joaquin of the National Immigration Law Center, one of the groups pushing a separate challenge to the law.

Kansas attorney Kris Kobach, who helped draft the law and has advised officials in other states wanting to crack down on illegal immigration, called the ruling "a big victory for Arizona" while acknowledging that "it's not a complete victory."

The ruling gives states "a green light" to enact "check your papers" laws, as well as other initiatives, such as requiring employers to use the federal E-Verify database to check the status of new workers, said Kobach, a Republican who is the Kansas secretary of state.

Arizona passed the law in 2010, with lawmakers arguing that that federal government wasn't adequately preventing illegal immigration. The Obama administration sued to block it, saying that enforcing immigration laws was a federal responsibility.

Federal courts had refused to let the four key provisions take effect.

Five states ? Alabama, Georgia, Indiana, South Carolina and Utah ? have adopted variations on Arizona's law. Parts of those laws also are on hold pending the outcome of the Supreme Court case.

Kobach said the decision was not a 100 percent victory for Arizona because "some of the less important provisions of the law were struck down." He added: "The reason can be summed up in two words: Justice Kennedy."

Justice Anthony Kennedy wrote the opinion for the court, a unanimous decision on allowing the status check to go forward. The court, however, was divided on striking down the other portions.

They were the sections that required all immigrants to obtain or carry immigration registration papers and allowed police to arrest suspected illegal immigrants without warrants.

Arizona has spent almost $3 million defending the law for the last two years, the Arizona Republic reported Monday.

In the Phoenix area, some residents were pleased that most of the law was tossed out.

Audrey Pulido, who owns The Garage Bike Shop in the predominantly Hispanic town of Guadalupe, also said that it was unfair that police can check a person's immigration status.

"Actually what you're doing is you're stereotyping a person," said Pulido, whose husband was in the U.S. illegally before they were married. "It's like judging a book before you even read it, just by what they are. They are human beings, first of all."

Pulido said residents do not talk much about the law but that it has instilled fear in them and factors into how they plan their lives.

Pulido said a waitress in the restaurant next door asked her if she would sign a notarized document to care for her son if the woman got deported. "I would do it in a heartbeat," she said. "I would not hesitate.

"You don't get that all the time," Pulido said. "They have to think that way ? 'What's going to happen to me?'"

___

Associated Press writers Mark Sherman in Washington; Terry Tang and Felicia Fonseca in Phoenix; and John Hanna in Topeka, Kan., contributed to this report.

Associated Press

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Monday, June 25, 2012

Pok?mon: New Beginnings

Pokemon: New Beginnings

A one-on-one roleplay between Patcharoo and Beta Type Jakuri.

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